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1. ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
ADAR1 promotes resistance to immune checkpoint blockade (ICB) by suppressing immunogenic Z-RNAs, which activate ZBP1-dependent necroptosis. The curaxin CBL0137 overcomes this resistance by inducing ZBP1-mediated necroptosis, revitalizing ICB efficacy in resistant cancers.
2. Z-DNA formation in promoters conserved between human and mouse are associated with increased transcription reinitiation rates
This study reveals that conserved Z-DNA-forming sequences (Z-flipons) in human and mouse promoters enhance transcription reinitiation rates without affecting elongation, particularly in neurodevelopmental genes. Using deep learning (DeepZ) and experimental validation, the authors demonstrate that Z-flipons dynamically regulate gene expression by resetting transcription complexes or recruiting repressive chromatin machinery.
3. Deep learning approach for predicting functional Z-DNA regions using omics data
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